Recent research has pointed to a possible link between low levels Vitamin B12. And the development of the non-alcoholic the disease of fatty liver (NAFLD) which is a condition that is characterized by excessive cholesterol accumulation within the liver. Experts believe that B12 deficiency could disrupt important metabolism pathways in the liver. Leading to the accumulation of fat and inflammation.

For patients with this condition the symptoms can include constant fatigue. A sensation of discomfort or fullness in the abdomen region and unproved weight fluctuations. They can be accompanied by signs of B12 deficiency like weakening. Numbness or tingling in the limbs, mental issues and anemia. The risk elements for these conditions generally are the same. Which include the unhealthy diet or weight gain, as well as metabolic syndrome.

To better understand the connection researchers have been focusing on the ways that a deficiency of B12 can increase homocysteine levels. Which is a dangerous amino acid. Homocysteine levels that are high can impair a vital liver protein called syntaxin 17. Which causes a disruption in fat metabolism. It is encouraging to note that in the case of experimental models supplementing B12 (along with Folic acid) has restored the function of the protein. It also reduced inflammation and even reversed the process of fibrosis.

Further studies on human subjects confirm this finding: patients suffering from NAFLD are, on average lower blood B12 levels than those with no liver disease. In a pilot clinical trial that included patients who took daily B12 supplementation experienced a drop in homocysteine levels as well as improved liver enzymes.

But, there is no clarity. Studies on genetics suggest that there is a dual connection with the higher B12 levels could enhance the chance of NAFLD and NAFLD itself may raise the circulating B12 levels, possibly due to a change in metabolism of the liver. Some research suggests that the lower B12 as well as folate concentrations to the severity of the fibrosis of the liver.

Experts recommend screening early for B12 deficiency in people who are at risk of developing fatty liver disease. Treatment plans focus on diet food sources for B12 (like fish eggs, meat, eggs and dairy) and supplementation as required. Additionally being healthy, maintaining an appropriate weight, exercising regularly. And making lifestyle changes are crucial to ensuring the health of your liver.